Clinical Studies

In its promotion of easier weight loss research*** has shown that caffeine anhydrous is an effective ingredient for lowering an obese individual’s obesity risk and to help to prevent weight from building back on again once it has been lost.

Overall, the research**** that has shown that caffeine anhydrous helps with weight loss, waist circumference reduction, and a decrease in body mass helped to make caffeine anhydrous an ideal choice for safe and effective over the counter diet pills.

However, the advantages of including ß-phenylethylamine HCl into your weight loss program don’t stop there. This ingredient, which is also known as PEA, is recognized through clinical research** to provide alertness and mood support. These features are both are critical to maintaining motivation throughout the length of the diet.

In fact, research*** has shown that this ingredient’s mood support is adequately strong enough that it can help to counteract depression. As it is easy to become discouraged while dieting, this substance can provide vital support to ensuring that weight loss goals are reached.

When combined with daily exercise, research**** has also shown that the use of ß-phenylethylamine HCl can work as an intense fat burner to considerably accelerate weight loss and can encourage a more successful diet overall.

Other changes that clinical research** has noted as a result of the use of forskolin are in the composition of the body. When compared to placebo groups, those taking this ingredient experience a notably lower body fat percentage (BF%) and body fat mass (FM).

In terms of actual fat burning, scientific research*** has indicated that when this substance is being taken by dieters, it helps the body to increase the speed by which it burns fats. This effect is maximized when it is combined with cardio exercises on a regular basis.

When combined with exercises recommended by a doctor for the individual dieter’s unique fitness level, the increased fat burning and the promotion of muscle growth has been shown in clinical study to have a considerable impact on a dieter’s ability to lose weight more quickly and easily.

NeOpuntia® is a well-researched weight management pill ingredient extracted from a plant called opuntia ficus-indica. After having been used in traditional medicine for hundreds of years, the plant underwent a great deal of scientific and clinical scrutiny for a series of medical purposes such as weight loss.

The findings have made it one of the most well recognized fat binder ingredients in high-quality supplements. For instance, one large study* followed patients suffering from metabolic syndrome. When they used NeOpuntia, the participants saw measurable improvements in their cardiovascular risk related blood lipid parameters.

More research**, this time in the form of a randomized clinical trial analysis examined the results of several studies. This revealed a link between opuntia ficus-indica supplementation and significant reductions in total blood pressure, cholesterol and body fat percentage levels. Though this analysis did underscore the fact that additional study would be required before the ingredient could be fully understood, it revealed a strong link between using this substance and experiencing a spectrum of support to lower health risks, including the reduction of body fat percentage.

Furthermore, a third study*** illustrated the way that using this ingredient can cause the level of fat excretion in the body to rise. Research participants consisting of healthy adults issued more dietary fat from their waste than another group of similar adults who were not given the supplement. This suggested a reduced dietary fat absorption when opuntia ficus-indica was used.

Organic Matcha Green Tea Leaf Powder is a powerful ingredient that is included in some of the most popular and well-respected quality supplements. The reason has to do with the wealth of research that has been conducted on this substance and the tremendous number of effects associated with its use.

This helps to explain why it can be found in some of the top weight management products available to consumers in the United States.

A respected study* revealed that when research participants used organic matcha green tea leaf powder supplements, those individuals experienced significant rises in their 24-hour energy expenditure. At the same time, those individuals who took the supplements also maintained higher adrenaline (norepinephrine) levels than the study participants who were given a placebo.

Another meaningful study** involved the use of green tea leaf supplements to research participants who subsequently experienced improvements to fat blocking (lipase inhibition) within the gastric and pancreatic systems. The dietary fat was blocked from being absorbed by the body through the reduction of the secretion of an important enzyme critical to fat digestion. In that same study, there was also a measurable increase in the study participants’ thermogenesis. This means that the supplements increased the participants’ body temperature, requiring more calories and/or body fat to be used to fuel that additional heat.

Therefore, studies suggest that this ingredient not only reduces the body’s absorption of dietary fats but also increases its rate of calorie and fat burning overall.

Theobromine is an ingredient seen in weight management pills due to the research supporting its effects. This substance used to be known as xantheose and is a bitter alkaloid that is extracted from the cacao plant – the same plant used for making chocolate. In fact, a certain amount of this ingredient is actually found in the chocolate we eat, in addition to other foods such as tea leaves and kola nut.

Despite what the name suggests, theobromine does not contain bromine. Instead, it is considered to be a xanthine alkaloid. On a chemical level, it isn’t entirely unlike caffeine and it does have a certain stimulant effect.

It is now well known for being used to help support dieters who are following a healthy and calorie controlled diet as well as a regular fitness appropriate activity level.

Of the body of research supporting the use of theobromine, one study* revealed that when taking this substance as a supplement, it can provide energy boosting and appetite suppression effects somewhat like caffeine. That said, this research showed that, when compared to the use of a placebo, this ingredient can be effectively combined with caffeine in order to improve the effects of that stimulant.

Acetyl-L-Carnitine HCl (ALCAR) is a substance sometimes selected for high-quality diet pill formulations because of the research conducted on it to better understand its benefits. It has a number of different effects on the body, many of which may be advantageous to people following a healthy diet and exercise program.

Acetyl-L-Carnitine HCl has undergone a substantial amount of research over the years. Many studies have pointed to its impact on the metabolism and the way in which it improves its rate. Other effects observed through the use of this substance include improved control over the symptoms of depression, enhanced brain function, and even having an antioxidant effect.

Within the body of research on this ingredient, one study* showed that ALCAR not only has an impact within the human body but that it continues to work over several hours after the supplement is administered. Participants given this substance experienced a gradual increase in its effects, to the point that they were still measurable 12 hours later. This is very helpful in making sure that the effects don’t wear away too quickly and that a user can rely on them.

When it comes to a faster metabolism, this can indicate that the body’s calorie and fat burning will speed up and remain at the higher level for a substantial period of time.

L-Tyrosine is a well-known ingredient that is occasionally selected for fitness and weight management supplements as a result of the positive outcomes it has received during clinical trials. Many dieters look specifically for products containing this substance due to the evidence describing its effects.

The substance itself is among the building blocks that make up protein. It is actually a substance the body can produce on its own from phenylalanine, an amino acid. That said, when it is supplemented, its effects can be magnified over what the body can accomplish on its own. Other sources of L-Tyrosine include oats, dairy, wheat, beans, nuts, fish, meats, and eggs.

One study* examining L-Tyrosine showed that when it is used in combination with other food-based ingredients (for instance, green tea and/or caffeine), the researchers determined that the individual’s thermogenic response was elevated. This means that the study participants’ temperatures rose, causing more calories from food and/or stored body fat to be used as a fuel for that additional heat.

Another study** revealed that when bioactive foods are consumed along with L-Tyrosine, thermogenesis increases over a significant amount of time. In this particular case, the research continued for 8 weeks. It was double-blind, placebo-controlled research involving the participation of subjects with obesity. The increased thermogenesis was measured over a period of 4 hours on average, with a rise of about 90 kj more than the placebo group.

Green coffee bean extract is an extremely hot ingredient at the moment due to the combination of positive attention it has received from respected members of the medical community as well as some very promising early research.

This natural ingredient has been the focus of a broad spectrum of preliminary studies in order to be able to ensure its safe use and to know exactly what effects it has in the body. Many people believe that we have only scratched the surface of what green coffee bean extract can do.

One of the studies* that has been considered to be one of the most promising when it comes to supporting dieters is one published in the BMC Complementary and Alternative Medicine journal which showed that it may offer a barrier against fat accumulation and weight gain. The reason is that it is believed to help the body to reduce the amount of dietary fat it absorbs. Moreover, it may reduce the liver’s metabolism of dietary fats filtered through it.

Another study** showed that green coffee bean extract supplementation helped dieters to reduce their overall body mass, weight and body fat percentage. This, despite the fact that the dieters had not made any significant changes to their eating habits. A decrease in heart rate was also measured, though that was more minor than the other observed effects. This study involved the participation of six subjects whose goal was to reduce their weight from the pre-obesity category and to bring it into the normal range. They were able to meet this goal. Prior animal studies had shown similar results to this preliminary experiment.

CLA, which stands for conjugated linoleic acid, is a natural ingredient that is sometimes used in high-quality weight management pills, fitness supplements and other products within the wellness industry. This substance can be obtained through a range of different sources, among which the most common are dairy and meat products.

Even when taken all by itself, CLA can provide a number of different health benefits and many people take it on its own as a supplement to improve overall wellness. That said, it can also be combined with a number of other substances in order to offer its users a more specific type of effect within the body including support for weight management.

One randomized, controlled trial study* on conjugated linoleic acid was conducted by teams of researchers from several scientific organizations in order to better understand the types of benefits it can provide. They determined that there was potential for weight loss, bodybuilding, and other similar areas. This research involved the participation of middle-aged men suffering from both obesity and metabolic syndrome. They used CLA supplements for a full month and, through this supplementation, they were able to lower their abdominal fat levels without placing these individuals at any further cardiovascular risk.

Eleuthero root extract, also known as Siberian ginseng or as Ciwujia, is a natural ingredient used in several types of wellness supplement, particularly in quality weight management pills. The substance is obtained from a small woody shrub that is found naturally in Eastern and Northeastern Asia.

Parts of this plant have been used for centuries in natural medicine. However, as modern medicine has taken the opportunity to study Eleuthero root extract, doctors have obtained a better understanding of just how it works and what it can do for its users. Many people use this substance as a stand-alone supplement for reasons ranging from common cold prevention to the reduction of symptoms from common illnesses. That said, it can also support those working to lose weight.

It’s important to note that Siberian Ginseng and Panax (American) Ginseng are not the same plant. They are not related and cannot be used interchangeably.

Eleuthero root extract works by promoting alertness and may boost in physical exercise performance. Dieters can benefit from that type of effect by getting more out of the workouts they complete in order to burn fat.

Reputable research supports the use of this ingredient for this purpose. For example, one study* illustrated the way in which this ingredient can function as an “adaptogen.” This means that it functions within the body to boost stress resistance and enhances vitality. In this way, it doesn’t just make sure people get the most out of their workouts, but it also ensures that it will have the smallest possible stress impact.

Xanthinol Nicotinate is a natural ingredient that is included in certain high-quality weight management supplements due to the positive results it has seen in scientific research. The medical community knows this substance as xanthinol niacinate. It is used as a type of vasodilator. This means that it works within the body by opening up the blood vessels, making it easier for blood to flow through them unrestricted.

Xanthinol Nicotinate is no stranger to scientific study. It has been looked into by many reputable organizations in order to help discover just why it works the way it does and to understand what dosage is safest and most effective at the same time.

In one German study* on this ingredient, it was examined for its effect on lipid reduction. They researched the impact of Xanthinol Nicotinate supplementation on patients who suffered from a condition called hyperlipoproteinemias. This condition occurs when the patient’s body is not able to properly break down lipids – that is, fats such as cholesterol and triglycerides. Those patients require medical assistance to be able to break down some of the fats they consume in their foods. In this research, the lipid-lowering effects of the ingredient looked very promising.

Cnidium Monnieri Fruit Powder is a natural ingredient used in medicinal supplements. It is also often known as Monier’s snow parsley. This ingredient is obtained from a plant within the cnidium genus, a flowering plant in the parsley family.

While it has been used in traditional Chinese medicine, more recent research has helped it to gain greater acceptance in conventional western medicine, as well. The benefits of this ingredient are believed to come from the coumarins within it. Coumarins are a form of phytochemical occurring naturally within certain plants. It is colorless, crystalline and has a notable fragrance that is often compared to that of vanilla.

Equally, this type of ingredient is also known to produce a number of different types of physiological effects within the body. There are three different coumarins found within the Cnidium Monnieri Fruit Powder often used in high-quality weight management supplements. These coumarins are imperatorin, xanthotoxol, and osthol.

One study* determined that Cnidium Monnieri Fruit Powder contains chromone glycosides which produce anti-adipogenic effects. What this means is that they may help the body to avoid gaining fat. The research results suggested that using this substance can significantly inhibit adipocyte differentiation. That effect was measured by the amount of 3T3-L1 cell fat accumulation which had notably reduced.

Throughout the careful and lengthy development process for FENFAST 375, the Intechra Health team quickly realized that L-Phenylalanine, an essential amino acid, should be included within its proprietary formula. Significant research indicated that this substance would be a solid complement to the other ingredients comprising these non-prescription tablets.

L-Phenylalanine is well known and recognized throughout the over the counter diet pill industry. Research has shown both safe and effective use when investigating its potential weight loss benefits. Studies have indicated that it works in the body through the production of cholecystokinin (CCK).

A scientific study* determined that the CCK produced in the bodies of the research’s human subjects following L-Phenylalanine supplementation effectively reduced their food intake. This helped the researchers to show that this ingredient can play a psychological role in controlling eating.

A later study** conducted on mice went on to discover more information about just why the body responded in that way to the presence of CCK. It determined that the CCK synergized acutely with amylin. Even lean mice reduced their food intake as a result. The researchers went on to suggest that this was meaningful evidence that indicated that studying potential therapeutic uses of CCK-based combinations for obesity patients.

That same research** also infused rats with a combination of amylin, leptin and CCK for 14 days and found that those rates lost a significant amount more body weight due to food intake inhibition than the rats with an amylin and leptin treatment alone.

When combined with a healthy, calorie-restricted diet, this type of effect could prove quite helpful to dieters. If a dieter is already naturally eating less, hunger pangs from dietary changes and calorie reduction may not pose as much of a challenge to them.